The COPSAC[sub]2000[/sub] cohort | COPSAC

The COPSAC2000 cohort

The COPSAC2000 cohort is a prospective clinical birth cohort study of 411 children of asthmatic mothers [1]. The study is designed to assess gene-environment interactions in the origin of atopic diseases with an aim to identify early-life exposures that can be modified to improve preventive strategies.

The children attend the COPSAC clinical research unit from birth till adolescence at six-monthly intervals for scheduled clinical investigations according to standard operating procedures, and additional visits are arranged at onset of any respiratory or skin symptom.

Clinical outcomes comprise preasthma, asthma, eczema, allergic rhinitis, allergy, lung function and bronchial responsiveness.

Exposure assessments comprise respiratory, intestinal and skin microbiology; the child's diet; indoor and outdoor air quality; allergens; and indicators of life style.

Genetics of probands and parents is assessed.

References

  1. Bisgaard H. "The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study." Annals of Allergy Asthma & Immunology. 2004;93:381-389.
COPSAC • Faculty of Health Sciences • University of Copenhagen • Denmark
Danish Pediatric Asthma Center • Copenhagen University Hospital
Ledreborg Alle 34 • 2820 Gentofte • phone +45 3977 7360 • contact@copsac.com
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