Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy.

DOI:

10.1164/rccm.201108-1471OC

Abstract:

Rationale: Heredity from mother or father may impact differently in complex diseases such as atopy. Maternal atopy is a stronger risk factor than paternal atopy for the development of atopy in the offspring. We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosa lining fluid of healthy neonates. Objectives: We wished to study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosa lining fluid of healthy neonates. Methods: 18 cytokines and chemokines were quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) birth cohort. Measurements and Main Results: Maternal, but not paternal, atopic status (asthma, hay fever and/or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P=0.015). Conclusions: Maternal atopy, but not paternal atopy, showed a strong linkage with a suppressed mucosal cytokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.

Attachment	Size
Følsgaard et al. - 2012 - Neonatal Cytokine Profile in the Airway Mucosal Li.pdf	245.42 KB