Randomized Trial

A main hypothesis of the COPSAC₂₀₁₀ birth cohort study is that protective factors in maternal diet during pregnancy influence maturation and regulation of neonatal immune responses directly or through modification of the mucosal microbiota and provide an opportunity for preventive supplementation in pregnancy.

We propose that a "gene-diet-microbe" interaction during pregnancy and early life contributes to an increaesed propensity of asthma and related atopic disorders in childhood.

Therefore, nested within the COPSAC₂₀₁₀ birth cohort, we conduct a randomized clinical intervention trial to study the influence of maternal supplementation with marine n-3 polyunsaturated fatty acids (n-3 PUFA) and/or vitamin D on disease development.